منابع مشابه
Actomyosin meshwork mechanosensing enables tissue shape to orient cell force
Sculpting organism shape requires that cells produce forces with proper directionality. Thus, it is critical to understand how cells orient the cytoskeleton to produce forces that deform tissues. During Drosophila gastrulation, actomyosin contraction in ventral cells generates a long, narrow epithelial furrow, termed the ventral furrow, in which actomyosin fibres and tension are directed along ...
متن کاملCell contacts orient some cell division axes in the Caenorhabditis elegans embryo
Cells of the early Caenorhabditis elegans embryo divide in an invariant pattern. Here I show that the division axes of some early cells (EMS and E) are controlled by specific cell-cell contacts (EMS-P2 or E-P3 contact). Altering the orientation of contact between these cells alters the axis along which the mitotic spindle is established, and hence the orientation of cell division. Contact-depen...
متن کاملOrgan Shape: Controlling Oriented Cell Division
One mechanism by which organisms control the shape of growing organs is by regulating the orientation of cell divisions. This occurs in the Drosophila wing under the control of genes previously implicated in regulating cell polarity.
متن کاملExtrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts.
Cell polarity must be integrated with tissue polarity for proper development. The Drosophila embryonic central nervous system (CNS) is a highly polarized tissue; neuroblasts occupy the most apical layer of cells within the CNS, and lie just basal to the neural epithelium. Neuroblasts are the CNS progenitor cells and undergo multiple rounds of asymmetric cell division, ;budding off' smaller daug...
متن کاملCadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia.
Oriented cell division is a fundamental determinant of tissue organization. Simple epithelia divide symmetrically in the plane of the monolayer to preserve organ structure during epithelial morphogenesis and tissue turnover. For this to occur, mitotic spindles must be stringently oriented in the Z-axis, thereby establishing the perpendicular division plane between daughter cells. Spatial cues a...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2016
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2016.03.005